1. García-Revilla, A. Boza-Serrano, Y. Jin, I. Martinsson, O. Klementieva, R. Ruiz, F. Aprile, T. Deierborg, J. L.Venero.
Deletion of Galectin-3, a new endogenous regulator of α-synuclein aggregation, protects dopaminergic system in a model of Parkinson’s Disease.
Acta Neuropathologica, Manuscript ID: ANEU-D-22-00826 just accepted
2. I.A. Neves Da Silva, N.Gvazava, I.Putra Wendi, R.Guinea, F. García Giménez, J. Stegmayr, Klementieva, D. E.Wagner
Formalin free fixation and xylene free tissue processing preserves cell-hydrogel interactions for histological evaluation of 3D calcium alginate tissue engineered constructs.
Front. Biomater. Sci., 17 April 2023 Sec. Biomaterials Science for Regenerative Therapies
3. C. Prater, Y. Bai, S.C. Konings, I. Martinsson, V. S. Swaminathan, P. Nordenfelt, G.Gouras, F. Borondics, O. Klementieva*,
Fluorescently guided optical photothermal infrared microspectroscopy for protein-specific bioimaging at subcellular level, J. Med. Chem. 2023, 66, 4, 2542–2549DOI: 10.1021/acs.jmedchem.2c01359.
4. A. Paulus, S.Yogarasa, M. Kansiz, I. Martinsson, G. Gouras, T. Deierborg, A. Engdahl, F. Borondics, Klementieva*
Correlative imaging to resolve molecular structures in individual cells: Substrate validation study for super-resolution infrared microspectroscopy.
Nanomedicine. 2022 Jul;43:102563. DOI: 10.1016/j.nano.2022.102563.
5. S. Bachiller, I. Hidalgo, M.G. Garcia, A. Boza-Serrano, A. Paulus, Q. Denis, C. Haikal, O. Manouchehrian, Klementieva, J.Y. Li, C.J. Pronk, G.K. Gouras, T.Deierborg
Early-life stress elicits peripheral and brain immune activation differently in wild type and 5xFAD mice in a sex-specific manner.
J Neuroinflammation. 2022 Jun 15;19(1):151. DOI: 10.1186/s12974-022-02515-w.
6. M.Solomon, V. Foderà, A.E. Langkilde, P. Elliott, F.Tagliavini, T. Forsyth T, Klementieva* and V. Bellotti
Recommendations for addressing the translational gap between experimental and clinical research on amyloid diseases.
- Transl Med. 2022 May 13;20(1):213. DOI: 10.1186/s12967-022-03420-9.
7. C. Azevedo, G. Teku, Y. Pomeshchik, J.F. Reyes, M. Chumarina, K.Russ, E. Savchenko, A. Hammarberg, N.J. Lamas, A. Collin, G.K. Gouras, Klementieva, M. Hallbeck, R. Taipa, M. Vihinen, L. Roybon
Parkinson’s disease and multiple system atrophy patient iPSC-derived oligodendrocytes exhibit alpha-synuclein-induced changes in maturation and immune reactive properties.
Proc Natl Acad Sci U S A. 2022 Mar 22;119(12):e2111405119.
8. R. O. Freitas, A. Cernescu, A. Engdahl, A. Paulus, J. E. Levandoski, I.Martinsson, E. Hebisch, C. Sandt, G. K. Gouras, C. N. Prinz, T. Deierborg, F. Borondics, Klementieva*
Nano-infrared imaging of primary neurons
Cells, 2021 Sep 27;10(10):2559. DOI: 10.3390/cells10102559.
Cells | Free Full-Text | Nano-Infrared Imaging of Primary Neurons (mdpi.com)
9. N. Gustavsson, E. Savchenko, Klementieva* and L. Roybon
The intracellular milieu of Parkinson’s disease patient brain cells modulates alpha-synuclein protein aggregation
Acta Neuropathologica Communications 2021 Sep 16;9(1):153.
10. N.Benseny-Cases, E. Álvarez-Marimon, E. Aso, M. Carmona, Klementieva, D. Appelhans, I. Ferrer, J. Cladera
In situ identification and G4-PPI-His-Mal-dendrimer-induced reduction of early-stage amyloid aggregates in Alzheimer’s disease transgenic mice using synchrotron-based infrared imaging
Scientific Reports 2021 Sep 15;11(1):18368. DOI: 10.1038/s41598-021-96379-4.
- N. Gustavsson, A. Paulus, A. Engdahl, K. Medjoubi, K. Klementiev, A. Somogyi, T. Deierborg,F.Borondics, G.K Gouras, O.Klementieva*
Correlative optical photothermal infrared and X-ray fluorescence for chemical imaging of trace elements and relevant molecular structures directly in neurons.
Nature:Light Sci Appl 2021 Jul 22;10(1):151. DOI: 10.1038/s41377-021-00590-x.
12. Y. Pomeshchik, Klementieva, J. Gil, I. Martinsson, M.G. Hansen, T. de Vries, A. Sancho-Balsells, K. Russ, E. Savchenko, A. Collin, A.R.Vaz, S. Bagnoli, B. Nacmias, C. Rampon, S. Sorbi, D. Brites, G. Marko-Varga, Z. Kokaia, M. Rezeli, G.K. Gouras, L. Roybon
Human iPSC-derived hippocampal spheroids: An innovative tool for stratifying Alzheimer disease patient-specific cellular phenotypes and developing therapies.
Stem Cell Reports. 2021 Nov 9;16(11):2838. DOI: 10.1016/j.stemcr.2021.10.003
13. A.Paulus, A. Engdahl, Y. Yang, A. Boza-Serrano, S. Bachiller, L.Torres-Garcia, A. Svanbergsson, MG Garcia, GK Gouras, JY Li, T. Deierborg, Klementieva*
Amyloid Structural Changes Studied by Infrared Microspectroscopy in Bigenic Cellular Models of Alzheimer’s Disease.
Int J Mol Sci. 2021 Mar 26;22(7):3430. DOI: 10.3390/ijms22073430
- O.Klementieva*, C. Sandt, I. Martinsson, M. Kansiz, G. K. Gouras, F. Borodnics
Super-Resolution Infrared Imaging of Polymorphic Amyloid Aggregates Directly in Neurons.
Advanced Science, 2020. 7, 1903004. DOI: 10.1002/advs.201903004
15. E. Aso, I. Martinsson, D. Appelhans,C. Effenberg, N. Benseny-Cases, J. Cladera, G Gouras, I. Ferrer, O.Klementieva*
Poly(propylene imine) dendrimers with histidine-maltose shell as novel type of nanoparticles for synapse and memory protection.
Nanomedicine. 2019 Apr;17:198-209 DOI: 10.1016/j.nano.2019.01.010
- N. Gustavsson, A. Marote, Y. Pomeshchik, K. Russ, C. Azevedo, M. Chumarina, S. Goldwurm, A. Collin, L Pinto, A.J. Salgado, O. Klementieva, L.Roybon, E. Savchenko
Generation of an induced pluripotent stem cell line (CSC-46) from a patient with Parkinson’s disease carrying a novel p.R301C mutation in the GBA gene.
Stem Cell Res. 2019 Jan;34:101373. DOI: 10.1016/j.scr.2018.101373
17. C. Wang, I. Iashchishyn, S. Nyström, Klementieva, J. Kara, S. Bengtsson, V. Fodera, V. Vetri, G. Sancataldo, I. Horwath, R. Moskalenko, R. Rofougaran, T. Bäckström, M. Wang, G. Gouras, N. Marklund, S.K. Shankar, L. Morozova-Roche
S100A9-Driven Amyloid-Neuroinflammatory Cascade in Traumatic Brain Injury and Alzheimer’s Disease.
Sci Rep. 2018 Aug 27;8(1):12836. DOI: 10.1038/s41598-018-31141-x
18. T.T. Olsson, Klementieva, G. K. Gouras:
Prion-like seeding and nucleation of intracellular amyloid-β.
Neurobiology of Disease 2018 Volume 113, 2018. DOI:10.1016/j.nbd.2018.01.015
Prion-like seeding and nucleation of intracellular amyloid-β – ScienceDirect
19. Klementieva*, K. Willén, I. Martinsson, B. Israelsson, A. Engdahl, J. Cladera, P. Uvdal, G.K. Gouras
Pre-plaque conformational changes in Alzheimer’s disease-linked Aβ and APP.
Nature Communications, 2017 Mar 13;8:14726. DOI: 10.1038/ncomms14726
Pre-plaque conformational changes in Alzheimer’s disease-linked Aβ and APP | Nature Communications
20. R. Cardenes, C. Zhang, O. Klementieva, S. Werner, P. Guttmann, C. Pratsch, J. Cladera, B. Bijnens
3D membrane segmentation and quantification of intact thick cells using cryo soft X-ray transmission microscopy: A pilot study.
PLoS ONE 2017, 12(4): e0174324. DOI: 10.1371/journal.pone.0174324
21. N. Benseny-Cases, Klementieva, M. Cotte, I. Ferrer, J. Cladera
Microspectroscopy (μFTIR) reveals co-localization of lipid oxidation and amyloid plaques in human Alzheimer disease brains.
Analytical Chemistry, 2014; 86 (24):12047-54. DOI: 10.1021/ac502667b
22. Klementieva*, E. Aso, D. Filippini, N. Benseny-Cases, M.Carmona, S. Juvés, D. Appelhans, J. Cladera, I. Ferrer
Effect of polypropyleneimine glycodendrimers on β-amyloid aggregation in vitro and in APP/PS1 transgenic mice, as a model of brain amyloid deposition and Alzheimer’s disease.
Biomacromolecules, 2013;14(10):3570-80. DOI: 10.1021/bm400948z pg. 21
23. N. Benseny-Cases, Klementieva, J. Cladera
Dednrimers antiamyloidogenic potential in neurodegenerative diseases.
New Journal of Chemistry, 2012, 36, 211-216. DOI: 10.1039/C1NJ20469F
24. T. Wasiak, M. Ionov, K. Nieznanski, H. Nieznanska, Klementieva, M. Granell, J. Cladera, J.P. Majoral, A.M. Caminade, B.Klajnert
Phosphorus dendrimers affect Alzheimer’s (Aß1-28) peptide and MAP-Tau protein aggregation.
Molecular Pharmaceutics 2012; 9(3):458-469. DOI: 10.1021/mp2005627
25. N. Benseny-Cases, Klementieva, J. Malý, J. Cladera
Granular Non-fibrillar Aggregates and Toxicity in Alzheimer’s Disease.
Current Alzheimer Research, 2012;9(8):962-971. DOI:10.2174/156720512803251129
26. Klementieva, N. Benseny-Cases, A. Gella, D. Appelhans, B. Voit, and J. Cladera
Dense Shell Glycodendrimers as Potential Non-toxic Antiamyloidogenic Agents in Alzheimer’s Disease. Biomacromolecules, 2011;12(11):3903-3909. DOI: 10.1021/bm2008636
Conference Proceedings Articles:
1. C.Prater, Y. Bei, F. Borondics, Klementieva
Protein-specific infrared spectroscopic imaging at sub-micrometer resolution with fluorescently guided optical photothermal infrared microscopy
Proceedings Volume PC12392, Advanced Chemical Microscopy for Life Science and Translational Medicine 2023;
SPIE, Biophotonics West PC123920O (2023) https://doi.org/10.1117/12.2649925
2. C.B. Prater, M.Kansiz, K. Kjoller, R. Shetty, F. Borondics, and Klementieva* Fluorescence-guided optical photothermal infrared (O-PTIR) spectroscopy
Proceedings Volume PC11973, Advanced Chemical Microscopy for Life Science and Translational Medicine 2022;
SPIE, Biophotonics West PC11973 (2022) DOI: 10.1117/12.2615057
3. M. Kansiz, A. Spadea, J. Nallala, C. Lima, H. Muhamadali, J. Denbigh, J.Lawrence, G. Bakir, P. Gardner, N. Stone, R.Goodacre, K.Gough, Klementieva*
Review of life science applications using submicron O-PTIR and simultaneous Raman microscopy: a new paradigm in vibrational spectroscopy
SPIE, Biophotonics West Proc. SPIE 11656, Advanced Chemical Microscopy for Life Science and Translational Medicine 2021, 1165617 (2021); https://doi.org/10.1117/12.2578662
Books and chapters in books
1. O. Klementieva Glycodendrimers as Potential Multitalented Therapeutics in Alzheimer’s Disease. Neuroprotection – New Approaches and Prospects. In Tech Open. 2019 DOI: 10.5772/intechopen.88974
2. N. Benseny-Cases, Klementieva, J. Cladera: In vitro Oligomerization and Fibrillogenesis of Amyloid-beta Peptides. Protein Aggregation and Fibrillogenesis in Cerebral and Systemic Amyloid Disease. 2012; 65:53-74. ISBN 978-94-007-5416-4
3. D. Appelhans, N. Benseny, O. Klementiveva, M. Bryszewska, B. Klajnert, J. Cladera: Dendrimer -amyloid Aggregates Morphology and Cell Toxicity. Dendrimers in Biomedical Applications 2013; DOI:10.1039/9781849737296-00001